G protein-coupled receptors : structure, signaling, and physiology / edited by Sandra Siehler, Graeme Milligan.
"This text provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel sig...
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| Online Access: | Electronic book from EBSCO |
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| Other Authors: | |
| Format: | eBook |
| Language: | English |
| Published: | Cambridge : Cambridge University Press, ©2011. |
| Subjects: |
| Summary: | "This text provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The first chapters of this book illustrate the history of GPCRs based on distinct species and genomic information. This is followed by discussion of the homo- and hetero-oligomerization features of GPCRs, including receptors for glutamate, GABAB, dopamine, and chemokines. Several chapters are devoted to the key signaling features of GPCRs. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically -adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis"--Provided by publisher |
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| Physical Description: | 1 online resource (430 pages) |
| Bibliography: | Includes bibliographical references (pages 409-413) and index. |
| ISBN: | 9780511909917 0511909918 9780511907111 0511907117 9780521112086 0521112087 9780511760334 0511760337 1316086569 9781316086568 1282770888 9781282770881 9786612770883 6612770880 0511909160 9780511909160 0511905831 9780511905834 0511908415 9780511908415 |
| Access: | Access limited to authorized users. |