Drosophila melanogaster models of motor neuron disease /

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Bibliographic Details
Online Access:Electronic book from EBSCO
Other Authors: Cauchi, Ruben J. (Editor)
Format: eBook
Language:English
Published:New York : Nova Biomedical, [2013]
Series:Neurodegenerative diseases--laboratory and clinical research.
Subjects:
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245 0 0 |a Drosophila melanogaster models of motor neuron disease /  |c Ruben J. Cauchi, editor. 
264 1 |a New York :  |b Nova Biomedical,  |c [2013] 
300 |a 1 online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 1 |a Neurodegenerative diseases-laboratory and clinical research 
504 |a Includes bibliographical references and index. 
588 |a Description based on print version record. 
505 0 |a DROSOPHILA MELANOGASTER MODELS OF MOTOR NEURON DISEASE ; DROSOPHILA MELANOGASTER MODELS OF MOTOR NEURON DISEASE ; Library of Congress Cataloging-in-Publication Data ; CONTENTS ; PREFACE ; A RESPONSIBLE CHOICE OF MODEL ORGANISM ; Chapter 1 GENETICS OF MOTOR NEURON DISORDERS: FROM GENE DIVERSITY TO COMMON CELLULAR CONSPIRATORS IN SELECTIVE NEURONAL KILLING ; ABSTRACT ; ABBREVIATIONS ; INTRODUCTION ; 1. AMYOTROPHIC LATERAL SCLEROSIS ; 1.1. Common Pathogenic Mechanisms in ALS ; 1.1.1. Oxidative Stress and Mitochondrial Dysfunction; 1.1.2. Dysregulated Intracellular Membrane Trafficking. 
505 8 |a 1.1.3. Abnormal Axonal Transport and Cytoskeleton 1.1.4. Defective RNA Processing ; 1.1.5. Impaired proteostasis ; 2. HEREDITARY SPASTIC PARAPLEGIA ; 2.1. Common Pathogenic Mechanisms in HSP ; 2.1.1. Oxidative Stress and Mitochondrial Dysfunction ; 2.1.2. Dysregulated Intracellular Membrane Trafficking ; 2.1.3. Abnormal Axonal Transport and Cytoskeleton; 2.1.4. Defective Myelination and Lipid Metabolism; 3. CHARCOT-MARIE-TOOTH DISEASE ; 3.1. Common Pathogenic Mechanisms in CMT2 ; 3.1.1. Oxidative Stress and Mitochondrial Dysfunction ; 3.1.2. Dysregulated Intracellular Membrane Trafficking. 
505 8 |a 3.1.3. Abnormal Axonal Transport and Cytoskeleton 3.1.4. Defective Myelination and Lipid Metabolism ; 3.1.5. Impaired proteostasis ; 5. SPINAL MUSCULAR ATROPHIES AND OTHER MOTOR NEURON DISORDERS ; 5.1. Common Pathogenic Mechanisms in SMA and Other MNDs ; 5.1.1. Dysregulated Intracellular Membrane Trafficking ; 5.1.2. Abnormal Axonal Transport and Cytoskeleton ; 5.1.3. Defective RNA Processing ; 5.1.4. Impaired Proteostasis ; CONCLUSION ; ACKNOWLEDGMENTS ; ABOUT THE AUTHORS ; REFERENCES. 
505 8 |a Chapter 2 A SECRETED LIGAND FOR GROWTH CONE RECEPTORS, VAP MEDIATES THE CELLULAR PATHOLOGICAL DEFECTS IN ALS ABSTRACT; ABBREVIATIONS ; INTRODUCTION ; STUDIES ON MUTATIONS ASSOCIATED WITH FAMILIAL FORMS OF ALS ENABLE US TO UNDERSTAND THE CORE PATHOLOGY OF ALS ; DOMINANTLY INHERITED MISSENSE MUTATIONS IN VAP ARE ASSOCIATED WITH A FAMILIAL FORM OF ALS ; VAP IS AN ER TRANSMEMBRANE PROTEIN CONTAINING A MSP DOMAIN ; VAP FUNCTIONS IN NOVEL SIGNALLING PATHWAYS ; CLEAVAGE OF VAP RELEASES MSP DOMAIN-CONTAINING FRAGMENTS THAT ARE SECRETED. 
505 8 |a VAP ACTS AS A LIGAND FOR EPH RECEPTOR AND MEDIATES EPH SIGNALLING VAP MSP MEDIATES ROBO AND LAR RECEPTORS AND FUNCTIONS IN THE MAINTENANCE OF THE MITOCHONDRIA IN MUSCLE ; ALS MUTATION CAUSES TWO DIFFERENT TYPES OF DEFECTS: A FAILURE OF VAP SECRETION (LOSS-OF-FUNCTION) AND ER STRESS (GAIN-OF-FUNCTION) AND ER STRESS (GAIN-OF-FUNCTION OR TOXIC DEFECTS) ; CONCLUSION ; ABOUT THE AUTHORS ; REFERENCES ; Chapter 3 FLIES IN MOTION: WHAT DROSOPHILA CAN TELL US ABOUT AMYOTROPHIC LATERAL SCLEROSIS ; ABSTRACT ; INTRODUCTION ; ALS IN MODEL ORGANISMS: YEAST TO MICE ; Current Hypotheses for ALS. 
506 |a Access limited to authorized users. 
650 0 |a Amyotrophic lateral sclerosis. 
650 0 |a Motor neurons  |x Models. 
650 0 |a Drosophila melanogaster. 
700 1 |a Cauchi, Ruben J.,  |e editor. 
773 |t EBSCOhost Ebook Collection. 
776 0 8 |i Print version:  |t Drosophila melanogaster models of motor neuron disease  |d New York : Nova Biomedical, [2013]  |z 9781626187474 (hbk.)  |w (DLC) 2013937391 
830 0 |a Neurodegenerative diseases--laboratory and clinical research. 
856 4 0 |u http://ezproxy.lafayette.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=610688  |z Electronic book from EBSCO