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04741cam a2200517 i 4500 |
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ocn960447053 |
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OCoLC |
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20220818213019.0 |
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130408s2013 nyua ob 001 0 eng |
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|a 2019713811
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|a DLC
|b eng
|e rda
|c DLC
|d OCLCF
|d YDX
|d OCLCO
|d N$T
|d E7B
|d EBLCP
|d YDXCP
|d OTZ
|d UAB
|d AU@
|d STF
|d OCLCO
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019 |
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|a 854768436
|a 923670027
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|a 9781626187979
|q ebook
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|a 1626187975
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|z 1626187479
|q hbk.
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|z 9781626187474
|q hbk.
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|a (OCoLC)960447053
|z (OCoLC)854768436
|z (OCoLC)923670027
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|a pcc
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|a RC406.A24
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|a 595.77/4
|2 23
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|a LAFW
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|a Drosophila melanogaster models of motor neuron disease /
|c Ruben J. Cauchi, editor.
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|a New York :
|b Nova Biomedical,
|c [2013]
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|a 1 online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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490 |
1 |
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|a Neurodegenerative diseases-laboratory and clinical research
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|a Includes bibliographical references and index.
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|a Description based on print version record.
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|a DROSOPHILA MELANOGASTER MODELS OF MOTOR NEURON DISEASE ; DROSOPHILA MELANOGASTER MODELS OF MOTOR NEURON DISEASE ; Library of Congress Cataloging-in-Publication Data ; CONTENTS ; PREFACE ; A RESPONSIBLE CHOICE OF MODEL ORGANISM ; Chapter 1 GENETICS OF MOTOR NEURON DISORDERS: FROM GENE DIVERSITY TO COMMON CELLULAR CONSPIRATORS IN SELECTIVE NEURONAL KILLING ; ABSTRACT ; ABBREVIATIONS ; INTRODUCTION ; 1. AMYOTROPHIC LATERAL SCLEROSIS ; 1.1. Common Pathogenic Mechanisms in ALS ; 1.1.1. Oxidative Stress and Mitochondrial Dysfunction; 1.1.2. Dysregulated Intracellular Membrane Trafficking.
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|a 1.1.3. Abnormal Axonal Transport and Cytoskeleton 1.1.4. Defective RNA Processing ; 1.1.5. Impaired proteostasis ; 2. HEREDITARY SPASTIC PARAPLEGIA ; 2.1. Common Pathogenic Mechanisms in HSP ; 2.1.1. Oxidative Stress and Mitochondrial Dysfunction ; 2.1.2. Dysregulated Intracellular Membrane Trafficking ; 2.1.3. Abnormal Axonal Transport and Cytoskeleton; 2.1.4. Defective Myelination and Lipid Metabolism; 3. CHARCOT-MARIE-TOOTH DISEASE ; 3.1. Common Pathogenic Mechanisms in CMT2 ; 3.1.1. Oxidative Stress and Mitochondrial Dysfunction ; 3.1.2. Dysregulated Intracellular Membrane Trafficking.
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|a 3.1.3. Abnormal Axonal Transport and Cytoskeleton 3.1.4. Defective Myelination and Lipid Metabolism ; 3.1.5. Impaired proteostasis ; 5. SPINAL MUSCULAR ATROPHIES AND OTHER MOTOR NEURON DISORDERS ; 5.1. Common Pathogenic Mechanisms in SMA and Other MNDs ; 5.1.1. Dysregulated Intracellular Membrane Trafficking ; 5.1.2. Abnormal Axonal Transport and Cytoskeleton ; 5.1.3. Defective RNA Processing ; 5.1.4. Impaired Proteostasis ; CONCLUSION ; ACKNOWLEDGMENTS ; ABOUT THE AUTHORS ; REFERENCES.
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|a Chapter 2 A SECRETED LIGAND FOR GROWTH CONE RECEPTORS, VAP MEDIATES THE CELLULAR PATHOLOGICAL DEFECTS IN ALS ABSTRACT; ABBREVIATIONS ; INTRODUCTION ; STUDIES ON MUTATIONS ASSOCIATED WITH FAMILIAL FORMS OF ALS ENABLE US TO UNDERSTAND THE CORE PATHOLOGY OF ALS ; DOMINANTLY INHERITED MISSENSE MUTATIONS IN VAP ARE ASSOCIATED WITH A FAMILIAL FORM OF ALS ; VAP IS AN ER TRANSMEMBRANE PROTEIN CONTAINING A MSP DOMAIN ; VAP FUNCTIONS IN NOVEL SIGNALLING PATHWAYS ; CLEAVAGE OF VAP RELEASES MSP DOMAIN-CONTAINING FRAGMENTS THAT ARE SECRETED.
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|a VAP ACTS AS A LIGAND FOR EPH RECEPTOR AND MEDIATES EPH SIGNALLING VAP MSP MEDIATES ROBO AND LAR RECEPTORS AND FUNCTIONS IN THE MAINTENANCE OF THE MITOCHONDRIA IN MUSCLE ; ALS MUTATION CAUSES TWO DIFFERENT TYPES OF DEFECTS: A FAILURE OF VAP SECRETION (LOSS-OF-FUNCTION) AND ER STRESS (GAIN-OF-FUNCTION) AND ER STRESS (GAIN-OF-FUNCTION OR TOXIC DEFECTS) ; CONCLUSION ; ABOUT THE AUTHORS ; REFERENCES ; Chapter 3 FLIES IN MOTION: WHAT DROSOPHILA CAN TELL US ABOUT AMYOTROPHIC LATERAL SCLEROSIS ; ABSTRACT ; INTRODUCTION ; ALS IN MODEL ORGANISMS: YEAST TO MICE ; Current Hypotheses for ALS.
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|a Access limited to authorized users.
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650 |
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|a Amyotrophic lateral sclerosis.
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|a Motor neurons
|x Models.
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|a Drosophila melanogaster.
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700 |
1 |
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|a Cauchi, Ruben J.,
|e editor.
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773 |
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|t EBSCOhost Ebook Collection.
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776 |
0 |
8 |
|i Print version:
|t Drosophila melanogaster models of motor neuron disease
|d New York : Nova Biomedical, [2013]
|z 9781626187474 (hbk.)
|w (DLC) 2013937391
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830 |
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0 |
|a Neurodegenerative diseases--laboratory and clinical research.
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856 |
4 |
0 |
|u http://ezproxy.lafayette.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=610688
|z Electronic book from EBSCO
|