The p53 tumor suppressor pathway and cancer /
The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging?eld?rst considered p53 as a viral antigen and then as an oncogene that cooperates with activated ras in transforming primary cells in culture. Fueling the concept of p53 acting as a transf...
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| Online Access: | Electronic book from Springer Complete |
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| Other Authors: | |
| Format: | eBook |
| Language: | English |
| Published: | New York, NY : Springer, ©2005. |
| Series: | Protein reviews ;
v. 2. |
| Subjects: |
Table of Contents:
- The p53 Network
- The Three-Dimensional Structure of p53
- Transcriptional Activation by p53: Mechanisms and Targeted Genes
- Transcriptional Repression by the p53 Tumor Suppressor Protein
- Posttranslational Modifications of p53: Upstream Signaling Pathways
- p53 in Human Cancer
- Somatic and Inherited Mutations and Mutation-independent Mechanisms
- MDM2 and MDMX Regulators of p53 Activity
- p53 Family Members: p63 and p73
- The Oncogenic Activity of p53 Mutants
- Therapeutic Strategies Based on Pharmacological Modulation of p53 Pathway.